Dicarboxylic acids and derivatives
Medchemexpress LLC VNT-101 | 2894060-67-2 | 99.5% | 456.41 | 5 MG
VNT-101 is an orally active influenza A (IAV) inhibitor that disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex. It exhibits potent antiviral activity across multiple influenza A subtypes and robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. It can be used for the study of influenza A infection.
- Orally active influenza A (IAV) inhibitor.
- Disrupts NP-NP PPI to block NP oligomerization.
- Destabilizes the viral ribonucleoprotein (RNP) complex.
- Potent antiviral activity across multiple influenza A subtypes.
- Exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay.
- Demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus.
Medchemexpress LLC GlyH-101 | 328541-79-3 | 99.7% | 493.15 | 5 MG
GlyH-101 is a potent inhibitor of CFTR (Cystic Fibrosis Transmembrane conductance Regulator) and VSORC (Volume-Sensitive Outwardly Rectifying Chloride) conductance. It exhibits antiproliferative activity by inhibiting CFTR-like and VSORC currents and is intended for research use only.
- Potent CFTR inhibitor
- Potent and reversible VSORC inhibitor
- Exhibits antiproliferative activity in PCT and PS120 cells
- Inhibits CFTR-like current in PCT cells
- Inhibits VSORC current in PS120 and PCT cells
- Reduces cholera toxin-induced intestinal fluid secretion in mice
- Available as a solid, light yellow to yellow
- Soluble in DMSO
Medchemexpress LLC VH 101, acid | 2408341-97-7 | 98.8% | C28H35FN4O6S | 25 MG
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. It contains an E3 ligase ligand plus an alkyl linker with a terminal amine, making it ready for conjugation to a target protein ligand.
- Functionalized von-Hippel-Lindau (VHL) protein ligand
- For PROTAC research and development
- Contains an E3 ligase ligand
- Alkyl linker with terminal amine for conjugation
- VHL protein is a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes
- Used by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein
Medchemexpress LLC Lauroyl-L-carnitine (chloride) | 6919-91-1 | 98.1% | 100 MG
Lauroyl-L-carnitine chloride is an orally active metabolite. It significantly reverses the decrease in its target gene IL-10 and alleviates Crohn's-like colitis. This compound exhibits anti-inflammatory effects and improves both systemic and local phenotypes in TNBS mice.
- Orally active metabolite
- Significantly reverses decrease in IL-10
- Alleviates Crohn's-like colitis
- Exhibits anti-inflammatory effects
- Improves systemic and local phenotypes in TNBS mice
- For research use only
Medchemexpress LLC Lauroyl coenzyme A (lithium) | 190063-12-8 | 99% | 1 MG
Lauroyl coenzyme A lithium salt is an intermediary in fatty acid synthesis or metabolism. It is formed by combining long-chain fatty acids (specifically lauric acid) with coenzyme A. This compound plays a role in lipid biosynthesis and fatty acid transport, where coenzyme A acts as a transport molecule to facilitate the movement and targeting of specific compounds.
- Intermediary in fatty acid synthesis or metabolism.
- Formed by combining long-chain fatty acids (lauric acid) with coenzyme A.
- Involved in lipid biosynthesis and fatty acid transport.
- Coenzyme A acts as a transport molecule to help move and target specific compounds.
- Purity: 99%.
- Appearance: White to off-white solid.
Apexbio Technology LLC AS 101 106566-58-9 50mg
AS 101 (CAS 106566-58-9) chemically known as ammonium trichloro(dioxoethylene-O O -)tellurate is a non-toxic immunomodulatory small molecule that acts primarily by inhibiting interleukin-10 (IL-10) signaling In cell-based studies AS 101 reduces IL-10 production and suppresses mesangial cell proliferation in a dose-dependent manner It has been shown to decrease tyrosine phosphorylation and nuclear translocation of STAT3 correlating with inhibition of IL-10 activity AS 101 stimulates IL-2 secretion and enhances immune cell function in both human and murine models In animal studies systemic administration confers bone marrow-sparing effects during chemotherapy mitigates alopecia enhances survival in sepsis models and modulates cytokine production These properties support its utility in investigating immune regulation and potential therapeutic interventions targeting cytokine-mediated pathologies
Medchemexpress LLC Sodium lauroyl glutamate | 29923-31-7 | 95.8% | 100 MG
Sodium lauroyl glutamate is an anionic amino acid surfactant. It has the potential for irritant contact dermatitis and possible anti-irritating potential in a surfactant mixture on human skin. It is primarily used in cleaning products and has been shown to exhibit low irritation to nude mouse skin at 1% w/w for 1 hour. This product is for research use only and not sold to patients.
- Anionic amino acid surfactant.
- Low irritation to nude mouse skin at 1% w/w for 1 hour.
- Primarily used in cleaning products.
- Mild surfactant with a pH value of 5.41.
- For research use only.