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Organic compounds that contain two carboxyl groups; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from dicarboxylic acids.
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UCPH-101 is a potent excitatory amino acid transporter subtype 1 (EAAT1) inhibitor, demonstrating an IC50 of 0.66 μM. This compound is intended for research applications only and is not suitable for patient use.
Inhibits EAAT1 anion currents with a KD value of 0.34±0.03 μM (Hill=1.3±0.13, n≥9).
Causes a small but significant decrease in total expression levels of HA-EAAT1 and HA-GLAST in cells preincubated with 100 μM UCPH-101 (p=0.048).
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Lauroyl-L-carnitine chloride is an orally active metabolite. It significantly reverses the decrease in its target gene IL-10 and alleviates Crohn's-like colitis.
Orally active metabolite
Reverses decrease in IL-10 gene
Alleviates Crohn's-like colitis
Purity: 98.14%
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PHI-101 is an orally active potent third-generation inhibitor of FLT3 that overcomes resistance to multiple drug-resistant mutations It has potential for research in relapsed or refractory acute myeloid leukemia (AML)
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MG-101 (ALLN Calpain inhibitor-1 Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins
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