Dicarboxylic acids and derivatives
Medchemexpress LLC AVN-101 hydrochlorid 100mg | 1061354-48-0 | 100 MG
AVN-101 hydrochloride is a brain-penetrant, orally active small-molecule antagonist of the 5-HT7 serotonin receptor with additional affinity for 5-HT6, 5-HT2A/2C, histamine H1, and adrenergic α2 receptors. Supplied as a high-purity solid for preclinical CNS research.
- Potent 5-HT7 antagonist (Ki ≈ 153 pM) with multi-receptor activity.
- Brain-penetrant and orally active, suitable for in vivo studies.
- High purity (99.59%) solid suitable for analytical and biological assays.
- Molecular weight 340.9 g/mol; formula C21H25ClN2.
- Available in multiple sizes, including a 100 mg pack for small-scale studies.
Medchemexpress LLC PKUMDL-LC-101-D04 50mg | 2143896-83-5 | 378.94 g·mol⁻¹ | C14H23ClN4O2S2 | 50 MG
Small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) used as a research tool to study ferroptosis and inflammation. Reported activity includes an approximate pEC50 of 4.7 and an ability to increase GPX4 activity in biochemical assays. Supplied as a solid with good solubility in DMSO for assay preparation.
- Allosteric activation of glutathione peroxidase 4 with reported pEC50 ≈ 4.7.
- Shown to increase GPX4 activity to about 150% in biochemical assays.
- Useful for probing ferroptosis and inflammation pathways in preclinical research.
- Supplied as a solid with high DMSO solubility for convenient dilution and assay use.
- Vendor-reported molecular formula and molecular weight provided for analytical reference.
Selleck Chemical LLC NLX-101 S3510-5mg
NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 10mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms
Medchemexpress LLC ULK-101 25mg | 2443816-45-1 | 460.45 | C22H16F4N4OS | 25 MG
ULK-101 is a potent, selective small-molecule inhibitor of ULK1 used in cellular and biochemical research to suppress autophagy and sensitize cancer cells to nutrient stress.
- Potent ULK1 inhibition (IC50 = 1.6 nM) with lower activity on ULK2 (IC50 = 30 nM).
- High purity suitable for research applications (99.91%).
- Available as a powder in multiple pack sizes, including 25 MG, and as DMSO solution formats.
- Storage-stable when kept at recommended temperatures for powder and solutions.
- Molecular weight 460.45 and molecular formula C22H16F4N4OS.
Medchemexpress LLC Sulforhodamine 101 DHPE | 187099-99-6 | 1381.84 | 1mg
Sulforhodamine 101 DHPE is a fluorescent probe made from the conjugation of the phospholipid 1 2-dipalmitoyl-sn-glycero-3-PE to sulforhodamine 101 a red fluorescent dye that displays excitation/emission spectra of 586/605 nm respectively It integrates into phospholipid bilayers and has been used for imaging of solid supported lipid bilayers detection of protein-ligand binding on bilayers and to monitor colocalization of lipid probes in liposomes via resonance energy transfer (RET)
Apexbio Technology LLC LOXO-101 1223405-08-0 5mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Apexbio Technology LLC AS 101 106566-58-9 50mg
AS 101 (CAS 106566-58-9) chemically known as ammonium trichloro(dioxoethylene-O O -)tellurate is a non-toxic immunomodulatory small molecule that acts primarily by inhibiting interleukin-10 (IL-10) signaling In cell-based studies AS 101 reduces IL-10 production and suppresses mesangial cell proliferation in a dose-dependent manner It has been shown to decrease tyrosine phosphorylation and nuclear translocation of STAT3 correlating with inhibition of IL-10 activity AS 101 stimulates IL-2 secretion and enhances immune cell function in both human and murine models In animal studies systemic administration confers bone marrow-sparing effects during chemotherapy mitigates alopecia enhances survival in sepsis models and modulates cytokine production These properties support its utility in investigating immune regulation and potential therapeutic interventions targeting cytokine-mediated pathologies
Apexbio Technology LLC Sulforhodamine 101 60311-02-6 25mg
Sulforhodamine 101 (60311-02-6) is a red-emitting fluorescent dye primarily utilized as a selective marker for astrocytes Sulforhodamine 101 selectively accumulates in astrocytes enabling differentiation from surrounding neuronal populations In neurobiological studies using live tissue imaging including acute brain slice preparations the dye facilitates visualization of astroglial cell morphology and cellular dynamics Based on these properties Sulforhodamine 101 holds research potential in the study of astrocyte-specific responses morphological characteristics and cell cell interactions within neuronal tissues
Medchemexpress LLC ULK-101 50mg | 2443816-45-1 | 460.45 g/mol | C22H16F4N4OS | 50 MG
ULK-101 is a potent, selective small-molecule inhibitor of Unc-51-like autophagy-activating kinase 1 (ULK1) that suppresses autophagy and sensitizes cancer cells to nutrient stress. It is characterized in vitro with low-nanomolar activity against ULK1 and shows activity versus ULK2. Supplied as a powder for laboratory research use only.
Medchemexpress LLC ULK-101 100mg | 2443816-45-1 | 100 MG
ULK-101 is a potent and selective ULK1 inhibitor used in research to suppress autophagy and sensitize cancer cells to nutrient stress. It demonstrates high potency against ULK1 with reduced activity against ULK2.
- Selective ULK1 inhibition with IC50 ≈ 1.6 nM.
- Reduced activity against ULK2 (IC50 ≈ 30 nM).
- High chemical purity reported at 99.91%.
- Molecular formula C22H16F4N4OS and molecular weight 460.45.
- Supplied as a powder; common pack size 100 mg.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
Medchemexpress LLC PKUMDL-LC-101-D04 1g | 2143896-83-5 | 378.94 | C14H23ClN4O2S2 | 1 G
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) supplied as a hydrochloride research chemical. It increases GPX4 enzymatic activity (reported pEC50 = 4.7) and has been used in cell and animal studies to inhibit ferroptosis and reduce inflammation. Molecular formula C14H23ClN4O2S2; molecular weight 378.94 Da.
- Allosteric activator of glutathione peroxidase 4 (GPX4).
- Reported activity pEC50 = 4.7 in biochemical assays.
- Hydrochloride salt form for improved stability and handling.
- Molecular formula C14H23ClN4O2S2, molecular weight 378.94 Da.
- Provided as a research reagent; not for human use.
- Typical pack size: 1 g.
Medchemexpress LLC 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 100 MG
CUDC-101 is a small-molecule research compound that concurrently inhibits histone deacetylases (HDACs) and receptor tyrosine kinases EGFR and HER2. It is used in preclinical cancer research to study combined epigenetic and kinase-targeted therapies.
- Potent inhibition of HDAC, EGFR, and HER2 with IC50s of 4.4 nM, 2.4 nM, and 15.7 nM.
- Contains a hydroxamic acid moiety associated with HDAC activity.
- High purity (>98.0%) suitable for research applications.
- Soluble in DMSO at 25 mg/mL (approximately 57.54 mM; may require ultrasonic agitation).
- Molecular formula C24H26N4O4 and molecular weight 434.49 g/mol.
Medchemexpress LLC GlyH-101 | 328541-79-3 | MFCD01532954 | 99.7% | 493.15 g/mol | C19H15Br2N3O3 | 10 MG
GlyH-101 is a research-grade small-molecule inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). It is used in cellular and electrophysiological studies to block CFTR-mediated chloride conductance and has reported antiproliferative activity. Supplied as a purified, characterized compound for laboratory research.
- Potent CFTR inhibitor for cellular and electrophysiology assays.
- Reversible blockade of VSORC conductance.
- High purity (99.7%).
- Molecular weight 493.15 g/mol.
- Molecular formula C19H15Br2N3O3.
- Supplied as a 10 mg vial for research use.
Apexbio Technology LLC AS 101 106566-58-9 10mg
AS 101 (CAS 106566-58-9) chemically known as ammonium trichloro(dioxoethylene-O O -)tellurate is a non-toxic immunomodulatory small molecule that acts primarily by inhibiting interleukin-10 (IL-10) signaling In cell-based studies AS 101 reduces IL-10 production and suppresses mesangial cell proliferation in a dose-dependent manner It has been shown to decrease tyrosine phosphorylation and nuclear translocation of STAT3 correlating with inhibition of IL-10 activity AS 101 stimulates IL-2 secretion and enhances immune cell function in both human and murine models In animal studies systemic administration confers bone marrow-sparing effects during chemotherapy mitigates alopecia enhances survival in sepsis models and modulates cytokine production These properties support its utility in investigating immune regulation and potential therapeutic interventions targeting cytokine-mediated pathologies